Symptoms and Traits of Borderline Personality Disorder May Run In Families

Summary: Family members of people with borderline personality disorder share similarities in brain structure and personality traits as those diagnosed with the personality disorder. Findings may point toward a hereditary component to personality disorders.

Source: University of Toronto

Family members of those with borderline personality disorder (BPD) show similarities in their brains and personalities—and even interpret some facial expressions similarly, according to a series of studies by researchers at the University of Toronto.

“One of the more urgent questions I hear when I speak with family groups is whether the disorder can be passed down from parents to their children,” says Anthony C. Ruocco, professor, interim graduate chair and director of clinical training in U of T Scarborough’s department of psychological clinical science.

“We are among the first researchers to study how factors in addition to symptoms and personality traits might run in families with BPD.”

BPD is a personality disorder categorized in part by impulsivity and difficulty with emotional regulation. Studies into BPD tend to focus on those with the disorder, but Ruocco wanted to identify which social and biological factors, beyond a BPD diagnosis, run in families. He says these characteristics might offer clues into what causes the disorder to develop and what can prevent it.

Diagnoses other than BPD observed in relatives

Ruocco found symptoms of BPD persist in families beyond those who are actually diagnosed with the disorder. For example, relatives show the same bias toward sad facial expressions, a pattern of weakness and strength in self-regulatory skills and distinct brain activation patterns during impulse control.

Ruocco conducted his research in the Clinical Neurosciences Laboratory, where he acts as director. He compared 103 people with BPD, 73 first-degree biological relatives (parents, siblings and children) and 99 people with no history of psychiatric illness. Participants completed a range of tests, including interviews, questionnaires, emotion perception tests, problem-solving tasks and brain scans. Those findings informed four papers published between 2019 and 2021.

He found that both those with BPD and their relatives showed higher levels of depression and substance use disorders. Relatives also received similar psychiatric diagnoses and showed more personality traits associated with emotional dysregulation and impulsivity.

“Even though you don’t see the full BPD diagnosis commonly in first-degree relatives, even having a few of the symptoms can be quite impairing,” he says. “This research really brings into focus some of the mental health challenges that many relatives of people with BPD experience.”

Families see fear in sad faces

Families of someone with BPD are prone to interpersonal conflicts—and Ruocco wondered whether facial expressions play a role. Several parents told him they try to show no emotion when their child with BPD is upset, yet often receive the response, “Why are you mad at me?”

It’s well documented that people with BPD interpret facial expressions differently than those without the disorder, but Ruocco found their relatives do, too. When shown a sad expression, people with BPD and their relatives took longer to decode the emotion, and both were more likely to interpret it as fearful.

“This pattern could suggest a heightened sensitivity to signals of threat in families with BPD, which could lead to arguments between family members, for example,” he says. “It’s important to understand what we can do to better align social-emotional communication to improve family functioning.”

Strengths and weaknesses found in impulse control

Another part of the study looked at impulse control via brain imaging. Researchers measured oxygen levels in the frontal part of the brain when participants were shown images and told to withhold responses for certain pictures.

People with BPD activated their prefrontal cortex less than the control group with no psychiatric diagnoses, but relatives showed greater brain activity than both. This pattern could mean relatives use more brain resources to control impulses, or they use similar resources differently to regulate themselves.

Ruocco calls impulsivity “potentially the most dangerous symptom of BPD.” Reckless driving, binge eating, excessive spending and substance abuse are all examples of impulsivity. It’s also associated with self-harm and suicide.

Ruocco’s most recent paper examined which cognitive abilities are associated with impulsivity and BPD. These abilities are known as executive functions, which are the complex thinking skills used to identify goals and plan the steps to reach them.

People with BPD tend to struggle more with executive functions, and researchers expected relatives to show similar difficulties. But relatives who had no psychiatric illness showed both strengths and weaknesses. These relatives had stronger impulse control and abstract thinking abilities, though they also had less efficient problem-solving skills. This aligns with stories Ruocco heard from parents.

“People who have a child with BPD sometimes say to me, “We need to be able to better regulate ourselves to help regulate our child,’” he says. “These findings also might highlight the strengths in self-regulation that could protect the relatives of people with BPD from developing a psychiatric illness themselves.”

Funded by the Canadian Institutes of Health Research, Ruocco hopes his work can help validate the experiences of people with BPD and their families and inspire new directions for treatment.

“As we better understand these familial factors, we can start to integrate these findings into the treatments for families with BPD.”