psychotherapy
  • Home
  • Mental Health A-Z
    • Community Psychology
      • Cultural Psychology
        • Addiction
          • Abnormal Psychology
        • ADHD, Adult
    • ADHD, Childhood
      • Alcohol Use
    • Anorexia
    • Anxiety
    • APA Format
    • Behavioral Psychology
    • Binge Drinking
    • Binge Eating
    • Biological Psychology
    • Biopsychology
    • Bipolar Disorder
    • Brain Health
    • Caffeine Addiction
    • Cannabis Use
    • Child Development
    • Classical Conditioning
    • Clinical Psychology
    • Cognitive Behavioral Therapy
    • Cognitive Development
    • Cognitive Psychology
    • Color Psychology
    • Counseling Psychology
    • Cross-Cultural Psychology
    • Depression
    • Depression, Childhood
    • Development Psychology
    • Dreaming
    • Drug Use
    • DSM-5 E
    • Eating Disorders
    • Educational Psychology
    • Emotional Abuse
    • Agoraphobia
    • Antisocial Personality Disorder(APD)
    • Avoidant Personality Disorder(AVPD)
    • Borderline Personality Disorder
    • Borderline Personality Disorder(BPD)
    • Dependent Personality Disorder(DPD)
    • Brain Health
    • Debates in Psychology
    • Emotions
    • Experimental Psychology
    • Extroversion
    • Forensic Psychology
    • Generalized Anxiety Disorder
    • Goal Setting
    • Grief & Loss
    • Happiness
    • Health Psychology
    • Healthy Aging
    • Hierarchy of Needs
    • Holistic Health
    • Household Stress
    • Inspiration
    • Intelligence
    • Introversion
    • IQ Scores
    • Job Stress
    • Kleptomania
    • Learning Styles
    • LGBTQ
    • Loneliness
    • Mania and Hypomania
    • Marital Issues
    • Meditation
    • Memory
    • Mental Exercises
    • Mental Health Technology
    • Mindfulness
    • Mood Disorders
    • Motivation
    • Narcissistic Personality Disorder(NPD)
    • personality disorder
    • Psychoanalysis
    • Psychology
    • Self-Improvement
    • Relationships
    • Nature vs. Nurture
    • Nicotine Use
    • Nonverbal Communication
    • Obsessive-Compulsive Disorder
    • Online Therapy
    • Operant Conditioning
    • Opioid Use
    • Panic Disorder
    • Parenting Styles
    • Passive Aggression
    • Personal Growth
    • Personality Disorders
    • Personality Psychology
    • Personality Types
    • Phobias
    • Positive Psychology
    • Psychoanalysis
    • Psychologist Biographies
    • Psychology 101
    • Psychology Careers
    • Psychology Theories
    • Psychosexual Development
    • Psychosocial Development
    • Psychosocial Psychology
    • Psychotherapy
    • PTSD
    • Quit Smoking
    • Race and Identity
    • Recovery
    • Relationship Stress
    • Relationships
    • Schizophrenia
    • School Psychology
    • Self-Improvement
    • Obsessive-Compulsive Personality Disorder(OCD)
    • Paranoid Personality Disorder(PPD)
    • Schizoid Personality Disorder
    • Schizotypal Personality Disorder(SPD)
    • Selective mutism (SM)
    • Separation anxiety disorder
    • Sex Addiction
    • Sexuality
    • Shopping Addiction
    • Situational Stress
    • Sleep
    • Social Anxiety Disorder
    • Social Learning Theory
    • Social Psychology
    • Spirituality
    • Sports Psychology
    • Stress Management
    • Student Resources
    • Study Guides
    • Suicide
    • Technology Addiction
    • Therapy Types
    • Violence and Abuse
    • Workplace Bullying
    • Specific phobias
    • Sports
    • Stress Management
    • Theories
    • therapy
    • VIEW ALL
  • About Us
  • Contact
No Result
View All Result
  • Login
  • Home
  • Mental Health A-Z
    • Community Psychology
      • Cultural Psychology
        • Addiction
          • Abnormal Psychology
        • ADHD, Adult
    • ADHD, Childhood
      • Alcohol Use
    • Anorexia
    • Anxiety
    • APA Format
    • Behavioral Psychology
    • Binge Drinking
    • Binge Eating
    • Biological Psychology
    • Biopsychology
    • Bipolar Disorder
    • Brain Health
    • Caffeine Addiction
    • Cannabis Use
    • Child Development
    • Classical Conditioning
    • Clinical Psychology
    • Cognitive Behavioral Therapy
    • Cognitive Development
    • Cognitive Psychology
    • Color Psychology
    • Counseling Psychology
    • Cross-Cultural Psychology
    • Depression
    • Depression, Childhood
    • Development Psychology
    • Dreaming
    • Drug Use
    • DSM-5 E
    • Eating Disorders
    • Educational Psychology
    • Emotional Abuse
    • Agoraphobia
    • Antisocial Personality Disorder(APD)
    • Avoidant Personality Disorder(AVPD)
    • Borderline Personality Disorder
    • Borderline Personality Disorder(BPD)
    • Dependent Personality Disorder(DPD)
    • Brain Health
    • Debates in Psychology
    • Emotions
    • Experimental Psychology
    • Extroversion
    • Forensic Psychology
    • Generalized Anxiety Disorder
    • Goal Setting
    • Grief & Loss
    • Happiness
    • Health Psychology
    • Healthy Aging
    • Hierarchy of Needs
    • Holistic Health
    • Household Stress
    • Inspiration
    • Intelligence
    • Introversion
    • IQ Scores
    • Job Stress
    • Kleptomania
    • Learning Styles
    • LGBTQ
    • Loneliness
    • Mania and Hypomania
    • Marital Issues
    • Meditation
    • Memory
    • Mental Exercises
    • Mental Health Technology
    • Mindfulness
    • Mood Disorders
    • Motivation
    • Narcissistic Personality Disorder(NPD)
    • personality disorder
    • Psychoanalysis
    • Psychology
    • Self-Improvement
    • Relationships
    • Nature vs. Nurture
    • Nicotine Use
    • Nonverbal Communication
    • Obsessive-Compulsive Disorder
    • Online Therapy
    • Operant Conditioning
    • Opioid Use
    • Panic Disorder
    • Parenting Styles
    • Passive Aggression
    • Personal Growth
    • Personality Disorders
    • Personality Psychology
    • Personality Types
    • Phobias
    • Positive Psychology
    • Psychoanalysis
    • Psychologist Biographies
    • Psychology 101
    • Psychology Careers
    • Psychology Theories
    • Psychosexual Development
    • Psychosocial Development
    • Psychosocial Psychology
    • Psychotherapy
    • PTSD
    • Quit Smoking
    • Race and Identity
    • Recovery
    • Relationship Stress
    • Relationships
    • Schizophrenia
    • School Psychology
    • Self-Improvement
    • Obsessive-Compulsive Personality Disorder(OCD)
    • Paranoid Personality Disorder(PPD)
    • Schizoid Personality Disorder
    • Schizotypal Personality Disorder(SPD)
    • Selective mutism (SM)
    • Separation anxiety disorder
    • Sex Addiction
    • Sexuality
    • Shopping Addiction
    • Situational Stress
    • Sleep
    • Social Anxiety Disorder
    • Social Learning Theory
    • Social Psychology
    • Spirituality
    • Sports Psychology
    • Stress Management
    • Student Resources
    • Study Guides
    • Suicide
    • Technology Addiction
    • Therapy Types
    • Violence and Abuse
    • Workplace Bullying
    • Specific phobias
    • Sports
    • Stress Management
    • Theories
    • therapy
    • VIEW ALL
  • About Us
  • Contact
No Result
View All Result
psychotherapy
No Result
View All Result
Home Uncategorized

Study of LSD Microdosing Doesn’t Show a Therapeutic Effect

Mozhgan Jamshidi Eyni by Mozhgan Jamshidi Eyni
in Uncategorized
Study of LSD Microdosing Doesn’t Show a Therapeutic Effect

Summary: Researchers say they have found no evidence LSD microdosing improves mood or cognitive function.

Source: University of Chicago

Proponents of LSD “microdosing”—taking small amounts of the drug at regular intervals—claim it can improve mood and cognitive function. But new research by the University of Chicago has not found evidence to support those claims.

Harriet de Wit, Ph.D., Professor of Psychiatry and Behavioral Neuroscience at UChicago, noted that the study doesn’t disprove microdosing’s possible benefits, and that more investigation is needed. The study does show that taking small doses of LSD is safe. De Wit said the findings point to the important role scientists can play in testing the therapeutic claims made about recreational drugs.

“These drugs are already being used out in the world, and it’s important for us to test them under controlled conditions, ensure their safety and see whether there’s some validity to the benefits people claim,” she said. “That’s something that has been missing from the conversation.”

De Wit is the lead author on the study, which was published February 1 in Addiction Biology. Her laboratory has a long track record of studying the effects of recreational and abused drugs under controlled conditions. The study was supported in part by the Institute of Translational Medicine, an interdisciplinary partnership between numerous Chicago institutions dedicated to accelerating the discovery and development of new therapeutics.

De Wit and colleagues studied the effects of four repeated low doses of LSD, administered under lab conditions every three to four days. One group of participants received 13 micrograms of the drug, a second group received 26 micrograms, and the third received a placebo. To put these low doses into context, the doses of LSD that are used to “trip” or to get high are typically 100–200 micrograms, she said.

LSD was chosen for the study because it’s the most commonly used psychedelic drug in microdosing.

Participants received the drugs during five-hour, supervised laboratory sessions. They also attended a drug-free follow-up session three to four days after the last dose. Participants were not told what kind of drug was being tested in the study—whether it was a stimulant, a tranquilizer or a hallucinogen—or that the study was about microdosing.

“We removed any expectations that this was a psychedelic drug,” de Wit explained. “Because in the real world, people’s expectations can strongly influence their responses.”

Participants completed cognitive and emotional tasks both during the drug administration sessions and at the drug-free follow-up session, to assess their mood and mental performance. Some participants who received the higher dose reported feeling a modest “high” during the drug sessions, but the effects were mild.

The drug did not improve mood or affect participants’ performance on cognitive tests, either during the drug sessions or at the follow-up session.

De Wit said the results were a disappointing surprise. “Because so many people claim to have experienced benefits from microdosing, we expected to document some kind of beneficial effect under laboratory conditions,” she said.

There were also neurobiological reasons to expect that LSD might improve mood, because LSD acts through serotonin receptors, where traditional antidepressants are known to act.

“We can’t say necessarily that microdosing doesn’t work,” de Wit said. “All we can say is that, under these controlled circumstances, with this kind of participant, these doses, and these intervals, we didn’t see a robust effect.”

She also noted that outside the laboratory environment, people who microdose often have strong expectations of beneficial effects. “It is possible that these expectations contribute to the apparent benefits, or they may interact with the pharmacological effect of the the drug,” she said.

The study did confirm that microdosing LSD is safe. This was not a surprise, as previous human and animal studies have not found LSD to be toxic, even at high doses. Researchers measured participants’ heart rate, blood pressure, impairment and other vital signs and did not document any negative effects.

In fact, de Wit noted, participants appeared to build a tolerance to LSD over the course of the study, with the strongest “high” reported at the first session, and the perception of a drug effect diminishing at each subsequent session. That’s a good sign because it confirms the drug does not stay in the body or accumulate over time, she said.

The research was challenging to complete, in part because LSD is heavily regulated. De Wit’s lab required DEA, FDA and IRB (Institutional Review Boards) review and approval to do the study. The time commitment of attending multiple five-hour drug administration sessions also made it hard to recruit participants.

However, de Wit emphasized the importance of such research, especially as practices like microdosing become commercialized.

“There are a lot of companies getting into the drug business, either with psychedelic drugs, or drugs like cannabidiol,” she noted. “And really there’s not very much empirical support to back up their claims. So, I think we have a responsibility to investigate and validate the claims.”

Abstract

Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study

The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. 

Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. 

Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3–4 days, followed by a drug-free follow-up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. 

We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.

About this psychopharmacology research news

Author: Ilima Loomis
Source: University of Chicago
Contact: Ilima Loomis – University of Chicago

Original Research: Closed access.
“Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study” by Harriet de Wit et al. Addiction Biology

Staring at Yourself During Virtual Chats May Worsen Your Mood

Staring at Yourself During Virtual Chats May Worsen Your Mood

June 14, 2022
How to Uncover and Embrace Your Glimmers in Triggering Times

How to Uncover and Embrace Your Glimmers in Triggering Times

September 9, 2022
Ageism and health: Study shows close links

Ageism and health: Study shows close links

June 19, 2022
Exercise May Reduce Depression Symptoms and Boost Effects of Therapy

Exercise May Reduce Depression Symptoms and Boost Effects of Therapy

April 2, 2022
How Early Fears Play a Role in Future Anxiety and Depression

How Early Fears Play a Role in Future Anxiety and Depression

October 27, 2022
Observations in Macaques Present New Insights Into How Moms Kind Attachments to Their Newborns

Observations in Macaques Present New Insights Into How Moms Kind Attachments to Their Newborns

September 20, 2022
Sleep Loss Does Not Impact Ability to Assess Emotional Information

Sleep Loss Does Not Impact Ability to Assess Emotional Information

October 12, 2021

what is Body Dysmorphic Disorder?(BDD)

November 8, 2021

Nicotine withdrawal symptoms and how to cope

October 4, 2021

Impact of College Personality Course on Personality Unde

May 2, 2022

What are mania and hypomania?

October 1, 2021

Is the Brain Wired Differently in People With Addiction?

February 19, 2023

Brain Fog: Everything You Need to Know

October 15, 2021

Forensic Psychology

August 6, 2021

Health of Older People Is Tied to Motivation

October 21, 2021

Passive-Aggressive Behavior

July 14, 2021
psychotherapy

We bring you the best Counseling services around your life quality, be with us and ask for it in live support.

Categories

Kenud Healing Center

  • Healing Center of Kenud , N9 112 , London , Great Britain
  • +447700305907
  • Jamshidi@kenud.com

Recent News

Thyroid Hormones and Blood Sugar Linked to Major Depressive Disorder Severity

Thyroid Hormones and Blood Sugar Linked to Major Depressive Disorder Severity

June 20, 2023
Alterations in Alcohol Consumption Echo Depression Symptom Changes

Alterations in Alcohol Consumption Echo Depression Symptom Changes

June 18, 2023

© 2023 Psychological counseling Services by Dr. Mozhgan Jamshidi Eyni.

No Result
View All Result
  • Home
  • Mental Health A-Z
    • Community Psychology
      • Cultural Psychology
    • ADHD, Childhood
      • Alcohol Use
    • Anorexia
    • Anxiety
    • APA Format
    • Behavioral Psychology
    • Binge Drinking
    • Binge Eating
    • Biological Psychology
    • Biopsychology
    • Bipolar Disorder
    • Brain Health
    • Caffeine Addiction
    • Cannabis Use
    • Child Development
    • Classical Conditioning
    • Clinical Psychology
    • Cognitive Behavioral Therapy
    • Cognitive Development
    • Cognitive Psychology
    • Color Psychology
    • Counseling Psychology
    • Cross-Cultural Psychology
    • Depression
    • Depression, Childhood
    • Development Psychology
    • Dreaming
    • Drug Use
    • DSM-5 E
    • Eating Disorders
    • Educational Psychology
    • Emotional Abuse
    • Agoraphobia
    • Antisocial Personality Disorder(APD)
    • Avoidant Personality Disorder(AVPD)
    • Borderline Personality Disorder
    • Borderline Personality Disorder(BPD)
    • Dependent Personality Disorder(DPD)
    • Brain Health
    • Debates in Psychology
    • Emotions
    • Experimental Psychology
    • Extroversion
    • Forensic Psychology
    • Generalized Anxiety Disorder
    • Goal Setting
    • Grief & Loss
    • Happiness
    • Health Psychology
    • Healthy Aging
    • Hierarchy of Needs
    • Holistic Health
    • Household Stress
    • Inspiration
    • Intelligence
    • Introversion
    • IQ Scores
    • Job Stress
    • Kleptomania
    • Learning Styles
    • LGBTQ
    • Loneliness
    • Mania and Hypomania
    • Marital Issues
    • Meditation
    • Memory
    • Mental Exercises
    • Mental Health Technology
    • Mindfulness
    • Mood Disorders
    • Motivation
    • Narcissistic Personality Disorder(NPD)
    • personality disorder
    • Psychoanalysis
    • Psychology
    • Self-Improvement
    • Relationships
    • Nature vs. Nurture
    • Nicotine Use
    • Nonverbal Communication
    • Obsessive-Compulsive Disorder
    • Online Therapy
    • Operant Conditioning
    • Opioid Use
    • Panic Disorder
    • Parenting Styles
    • Passive Aggression
    • Personal Growth
    • Personality Disorders
    • Personality Psychology
    • Personality Types
    • Phobias
    • Positive Psychology
    • Psychoanalysis
    • Psychologist Biographies
    • Psychology 101
    • Psychology Careers
    • Psychology Theories
    • Psychosexual Development
    • Psychosocial Development
    • Psychosocial Psychology
    • Psychotherapy
    • PTSD
    • Quit Smoking
    • Race and Identity
    • Recovery
    • Relationship Stress
    • Relationships
    • Schizophrenia
    • School Psychology
    • Self-Improvement
    • Obsessive-Compulsive Personality Disorder(OCD)
    • Paranoid Personality Disorder(PPD)
    • Schizoid Personality Disorder
    • Schizotypal Personality Disorder(SPD)
    • Selective mutism (SM)
    • Separation anxiety disorder
    • Sex Addiction
    • Sexuality
    • Shopping Addiction
    • Situational Stress
    • Sleep
    • Social Anxiety Disorder
    • Social Learning Theory
    • Social Psychology
    • Spirituality
    • Sports Psychology
    • Stress Management
    • Student Resources
    • Study Guides
    • Suicide
    • Technology Addiction
    • Therapy Types
    • Violence and Abuse
    • Workplace Bullying
    • Specific phobias
    • Sports
    • Stress Management
    • Theories
    • therapy
    • VIEW ALL
  • About Us
  • Contact

© 2023 Psychological counseling Services by Dr. Mozhgan Jamshidi Eyni.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
-
00:00
00:00

Queue

Update Required Flash plugin
-
00:00
00:00
  • FR