Summary: An experimental diet that reduced the intake of omega-6 fatty acids and increased omega-3 fatty acids improved mood variability in those with bipolar disorder.
Source: Penn State
Can specific dietary guidelines help people living with bipolar disorders better manage their health? Maybe someday, according to a new study by Penn State College of Medicine researchers. Clinical trial results showed that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood.
Bipolar disorders, which affect up to 2.4% of the population, are mental health conditions where individuals experience cyclic and abnormally elevated and/or depressed mood states. During acute episodes, parts of the brain that regulate emotions are underactive, leading to either manic highs or depressive lows. Researchers are identifying ways to help patients with the symptoms they experience between episodes, which can include pain, anxiety, impulsivity and irritability.
“As clinicians, we understand that if we can help our patients better control these symptoms between episodes, it could help reduce the number of times they relapse into acute episodes,” said Dr. Erika Saunders, Shively-Tan Professor and chair of the Department of Psychiatry and Behavioral Health at Penn State Health Milton S. Hershey Medical Center.
“Our goal with this trial was to see if specific dietary interventions could help patients with mood variability between episodes.”
Saunders and her colleagues designed a diet to alter the levels of specific polyunsaturated fatty acids — nutrients found in many foods — participants consumed while participating in usual care for bipolar disorders, including mood-stabilizing medication.
Prior research showed that medications for treating bipolar disorders change the way bodies break down, or metabolize, fatty acids. The byproducts of this process activate different parts of the immune system and include other chemical processes that affect how the body perceives pain, a common symptom reported by people living with bipolar disorders.
The researchers hypothesized that by changing the type and amount of fatty acids consumed, the body would generate metabolites with specific purposes, such as reducing pain or inflammation.
The experimental diet decreased omega-6 fatty acid consumption by limiting red meat, eggs and certain oils, and increased omega-3 fatty acid consumption by adding flax seed and fatty fishes like tuna and salmon.
To keep participants unaware of which group they were in, the team gave participants specific meal plans with instructions on how to prepare their food as well as unlabeled cooking oils and specially prepared snack foods and baked products.
More than 80 people with bipolar disorders participated in diet counseling and were given specific foods to eat for a 12-week period. Twice a day they completed surveys on their mobile devices about their mood, pain and other symptoms.
Throughout the study participants also had bloodwork taken so researchers could measure fatty acid levels and how the food was affecting their bodies. According to the researchers, the experimental diet improved mood variability in patients with bipolar disorders.
The results were published in the journal Bipolar Disorders.
“At this time, we can’t yet recommend this type of diet for patients with bipolar disorders, although we found the diet to be safe,” said Saunders, noting that follow-up studies are needed. “This carefully constructed nutrition plan shows promise for regulating mood between manic and depressive episodes, but we’re not sure if this could be widely adopted since it would be challenging for patients to follow this rigorous program.”
In the future, the research team will continue to assess how fatty acid metabolites may affect pain in bipolar disorders. Saunders said that by replicating the study, they hope to make sound, scientific dietary recommendations for people with bipolar disorders that could be more easily implemented in their everyday lives.
“This diet isn’t meant to be a treatment for people with bipolar disorders who are experiencing acute, severe depression or mania,” Saunders said. “Rather, our goal is to develop solutions to help patients have better long-term management of their symptoms, including pain.”
Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy and Ming Wang of Penn State College of Medicine; Beth MacIntosh of University of North Carolina; and Anthony Domenichiello and Christopher Ramsden of the National Institute on Aging also contributed to this research. The authors report no conflicts of interest.
Funding: This project was funded by the Stanley Medical Research Institute (grant #13T-013). Additional support was provided by the National Institutes of Health through the National Institute on Aging, the National Institute on Alcohol Abuse and Alcoholism and the National Center for Advancing Translational Sciences through Penn State Clinical and Translational Science Institute (grant UL1 TR002014).
Adjunctive dietary intervention for bipolar disorder: a randomized, controlled, parallel‐group, modified double‐blinded trial of a high n‐3 plus low n‐6 diet
To investigate the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) when compared to dietary intervention with usual U.S. levels of n-6 and n-3 polyunsaturated fatty acid (PUFA) intakes (control diet, CD).
This 2-arm, parallel-group, randomized, modified double-blind, controlled 48-week study of 12-week intensive diet intervention in subjects with BD was conducted at a single suburban-rural site in the mid-Atlantic region. Participants with DSM-IV TR BD I or II with hypomanic or depressive symptoms were randomized, stratified on gender (N = 82). The intervention included the provision of group-specific study foods and dietary counseling. Variability of mood symptoms was measured by a twice-daily, 12-week ecological momentary analysis (EMA) paradigm, and group differences were analyzed using multilevel models. Circulating n-3 and n-6 fatty acids were measured at baseline and after 4, 8, and 12 weeks of diet exposure.
All 82 randomized participants were included in biochemical analyses. Seventy participants completed at least 2 EMA surveys and were included in primary EMA analyses. Variability in mood, energy, irritability, and pain as measured using EMA was reduced in the H3-L6 group compared to the CD group. No significant differences in mean ratings of mood symptoms, or any other symptom measures, were detected. The dietary intervention effect on target PUFAs significantly differed by the group over time.
A dietary intervention adjunctive to usual care showed preliminary efficacy in improving variability in mood symptoms in participants with BD.
Trial Registration: ClinicalTrials.Gov NCT02272010.
About this diet and bipolar disorder research news
Original Research: Closed access.
“Adjunctive dietary intervention for bipolar disorder: a randomized, controlled, parallel‐group, modified double‐blinded trial of a high n‐3 plus low n‐6 diet” by Erika F. H. Saunders, Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy, Beth MacIntosh, Anthony Domenichiello, Christopher E. Ramsden, Ming Wang. Bipolar Disorders